Hypochlorite oxidation causes cross-linking of Lp(a).

  title={Hypochlorite oxidation causes cross-linking of Lp(a).},
  author={A. M. O'Connell and Steven P Gieseg and Keith K. Stanley},
  journal={Biochimica et biophysica acta},
  volume={1225 2},
When purified low density lipoprotein (LDL) or lipoprotein(a) (Lp[a]) was oxidized in vitro using concentrations of hypochlorite (50-500 microM) which might be achieved by activated neutrophils in vivo, high molecular weight species were observed on SDS polyacrylamide gels. The reaction was concentration-, temperature- and time-dependent. The high molecular weight apoprotein complexes were resistant to heating in SDS and DTT, suggesting covalent, but non-disulfide bond, cross-linking… CONTINUE READING