Hypochlorite-induced damage to nucleosides: formation of chloramines and nitrogen-centered radicals.

@article{Hawkins2001HypochloriteinducedDT,
  title={Hypochlorite-induced damage to nucleosides: formation of chloramines and nitrogen-centered radicals.},
  author={C L Hawkins and Michael J Davies},
  journal={Chemical research in toxicology},
  year={2001},
  volume={14 8},
  pages={1071-81}
}
Stimulated monocytes and neutrophils generate hypochlorite (HOCl) via the release of the enzyme myeloperoxidase and hydrogen peroxide. HOCl is a key bactericidal agent, but can also damage host tissue. As there is a strong link between chronic inflammation and some cancers, we have investigated HOCl damage to DNA bases. We show that reaction of HOCl with the exocyclic -NH(2) groups of cytidine, adenosine, and guanosine, and the ring NH groups of all bases, yields chloramines (RNHCl/RR'NCl… CONTINUE READING

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