Hypocalcemia-like electrocardiographic changes after administration of intravenous fosphenytoin.

@article{Keegan2002HypocalcemialikeEC,
  title={Hypocalcemia-like electrocardiographic changes after administration of intravenous fosphenytoin.},
  author={Mark Keegan and Lois R. Bondy and Joseph L. Blackshear and William L. Lanier},
  journal={Mayo Clinic proceedings},
  year={2002},
  volume={77 6},
  pages={
          584-6
        }
}
Fosphenytoin is a prodrug that is metabolized by phosphatases to yield the antiepileptic drug phenytoin plus inorganic phosphate. Thus, fosphenytoin can theoretically alter the electrocardiogram by 2 mechanisms: the direct effects of phenytoin on cardiac conduction and on phosphate binding of calcium, which could indirectly alter cardiac conduction as a result of hypocalcemia. We report the case of a 23-year-old man, weight 73 kg, with a known but untreated seizure disorder who was given… 
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