Hypoalgesia induced by the local injection of phentolamine in the nucleus raphe magnus: blockade by depletion of spinal cord monoamines.


Blockade of the noradrenergic input to the nucleus raphe magnus (NRM) by the injection of alpha-adrenergic antagonists produces hypoalgesia. Previous studies show that this hypoalgesia is blocked by the intrathecal injection of either phentolamine or methysergide. The present study demonstrates that depletion of spinal cord serotonin, norepinephrine, or… (More)


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