Hypoalgesia elicited by a conditioned stimulus is blocked by a mu, but not a delta or a kappa, opioid antagonist injected into the rostral ventromedial medulla.


The present study investigated the role of micro, delta, and kappa receptors within the RVM in mediating expression of conditional hypoalgesia (CHA). Five groups of rats with RVM cannulae were given daily sessions of paired or unpaired presentations of an auditory CS (white noise) and foot shock across three consecutive days. On the test day, rats in the… (More)

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