Hypo-osmotic Shock-Induced Subclinical Inflammation of Skin in a Rat Model of Disrupted Skin Barrier Function

  title={Hypo-osmotic Shock-Induced Subclinical Inflammation of Skin in a Rat Model of Disrupted Skin Barrier Function},
  author={Chihiro Kishi and T. Minematsu and Lijuan Huang and Y. Mugita and A. Kitamura and G. Nakagami and Takumi Yamane and Mikako Yoshida and H. Noguchi and M. Funakubo and Taketoshi Mori and H. Sanada},
  journal={Biological Research For Nursing},
  pages={135 - 141}
Aging disrupts skin barrier function and induces xerosis accompanied by pruritus. In many cases, elderly patients complain of pruritus during skin hygiene care, a condition called aquagenic pruritus of the elderly (APE). To date, the pathophysiology and mechanism of action of APE have not been elucidated. We conducted the present study to test the hypothesis that hypo-osmotic shock of epidermal cells induces skin inflammation and elongation of C-fibers by nerve growth factor β (NGFβ) as a basic… Expand
Cell Volume Regulation in the Epidermis.
  • M. Jahn, O. Rauh, T. Fauth, C. Buerger
  • Medicine
  • Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology
  • 2021
Exosomal Vimentin from Adipocyte Progenitors Protects Fibroblasts against Osmotic Stress and Inhibits Apoptosis to Enhance Wound Healing


Intraepidermal nerve fibers increase in dry skin of acetone-treated mice.
Aging enhances maceration-induced ultrastructural alteration of the epidermis and impairment of skin barrier function.
Oral administration of collagen tripeptide improves dryness and pruritus in the acetone-induced dry skin model.
Aquagenic pruritus. Water-induced activation of acetylcholinesterase.
Dry skin in the elderly: complexities of a common problem.