Hypnotic effects of deoxycorformycin in rats

  title={Hypnotic effects of deoxycorformycin in rats},
  author={M. Radulova{\vc}ki and R. M. Virus and M. Djuricic-Nedelson and R. D. Green},
  journal={Brain Research},
  • M. Radulovački, R. M. Virus, +1 author R. D. Green
  • Published 1983
  • Medicine
  • Brain Research
  • Rats implanted with EEG and EMG electrodes were treated with deoxycoformycin (0.5 or 2.0 mg/kg, i.p.), and polygraphically recorded for 6 h. Deoxycoformycin is a potent inhibitor of adenosine deaminase and would be expected to elevate the levels of adenosine in the central nervous system. The 0.5 mg/kg dose of the drug increased REM sleep and reduced REM sleep latency while the dose of 2.0 mg/kg increased deep slow-wave sleep (S2). These results appear to be consistent with those reported… CONTINUE READING
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