Hypnotic and Anesthetic Interactions between Ketamine and Midazolam in Female Patients

  title={Hypnotic and Anesthetic Interactions between Ketamine and Midazolam in Female Patients},
  author={W. Hong and T. Short and T. W. Hui},
  • W. Hong, T. Short, T. W. Hui
  • Published 1993
  • Medicine
  • Anesthesiology
  • BackgroundMidazolam, if used with ketamine for induction and maintenance of anesthesia, may attenuate hyperdynamic circulatory effects and prevent undesirable emergenic reactions. The nature of the interaction between midazolam and ketamine used for anesthesia induction was studied in female patients. MethodsQuantal dose-response curves were determined in 170 female patients for the drugs, individually and in combination. Two endpoints were assessed, loss of response to verbal command (hypnosis… CONTINUE READING
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