Hypnic headache

  title={Hypnic headache},
  author={Mark Obermann and Dagny Holle},
  journal={Expert Review of Neurotherapeutics},
  pages={1391 - 1397}
Hypnic headache is a rare primary headache disorder that is characterized by exclusively sleep-related headache attacks in patients usually beyond 50 years of age. Only 174 cases have been reported in the literature so far. Owing to its low prevalence, clinical features and therapeutic options, as well as underlying pathophysiologic mechanisms, are widely unknown or being controversially discussed. The association of hypnic headache with rapid-eye movement sleep was strongly contradicted in… 
2 Citations
Hypnic headache: A review of 348 cases published from 1988 to 2018
Lithium and caffeine are effective drugs for pain prophylaxis, but randomized clinical trials are required.
Headache in the Elderly
With advancing age, the prevalence of primary headaches such as migraine, tension type and cluster declines, whilst that of the secondary headaches such as intracranial mass lesions, systemic disease


A Case of Symptomatic Hypnic Headache Syndrome
To the authors' knowledge, this is the first report of symptomatic hypnic headache that developed after stroke and that suggests direct evidence of a potential pathophysiological mechanism and relationship of hypnic headaches to the sleep cycle.
Secondary “hypnic headache-
It is suggested that 24 h ambulatory blood pressure monitoring may be included in the evaluation of nocturnal headache complaints especially in the elderly, in whom essential hypertension is a very frequent comorbidity.
Hypnic Headache: Another Indomethacin‐Responsive Headache Syndrome?
Hypnic headache syndrome appears to represent yet another headache disorder in which there is sometimes an impressive response to indomethacin, and lithium has been reported to be an effective treatment, but the side effects of this medication are sometimes prohibitive.
Hypnic Headache in Childhood?: A Case Report
A 9-year-old fulfilled the diagnostic criteria for hypnic headache, a rare, primary headache disorder of the elderly, that occurs exclusively during sleep without autonomic accompaniments.
Hypnic headache: an update
Sufficient evidence, mainly from polysomnographic studies, indicates that HH is a primary rapid eye movement (REM) sleep-related headache disorder of chronobiological origin and Lithium, melatonin, indomethacin and caffeine at bedtime are among the most effective therapeutic options.
Rare nocturnal headaches
There is growing evidence that cluster headache and hypnic headache are chronobiological disorders that have an indirect impact on the sleep-wake cycle.
Episodic Hypnic Headache?
The review of the published cases suggests that hypnic headache tends to be a chronic unremitting disorder.
The Hypnic (“Alarm Clock”) Headache Syndrome
Hypnic headache syndrome is a rare, sleep-related, benign headache disorder that largely remains unchanged or attenuates over time, but frequency may vary in either direction.
Posterior Fossa Meningioma Presenting as Hypnic Headache
A patient who presented with otherwise typical hypnic headache accompanied by longstanding bilateral deafness and minimal imbalance was described, and magnetic resonance imaging showed evidence of a posterior fossa meningioma.
Polysomnography in Hypnic Headache Syndrome
Three patients with long‐standing hypnic headache underwent overnight polysomnography and the results were quite variable, ranging from normal to marked sleep insufficiency.