Hypervitaminosis D mediates compensatory Ca2+ hyperabsorption in TRPV5 knockout mice.

Abstract

Vitamin D plays an important role in Ca(2+) homeostasis by controlling Ca(2+) (re)absorption in intestine, kidney, and bone. The epithelial Ca(2+) channel TRPV5 mediates the Ca(2+) entry step in active Ca(2+) reabsorption. TRPV5 knockout (TRPV5(-/-)) mice show impaired Ca(2+) reabsorption, hypercalciuria, hypervitaminosis D, and intestinal hyperabsorption… (More)

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@article{Renkema2005HypervitaminosisDM, title={Hypervitaminosis D mediates compensatory Ca2+ hyperabsorption in TRPV5 knockout mice.}, author={Kirsten Yvet Renkema and Tom Nijenhuis and Bram C. J. van der Eerden and Annemiete W C M van der Kemp and Harrie Weinans and Johannes P T M van Leeuwen and Ren{\'e} J M Bindels and Joost G. J. Hoenderop}, journal={Journal of the American Society of Nephrology : JASN}, year={2005}, volume={16 11}, pages={3188-95} }