Hypervariable ultra-long telomeres in mice

@article{Kipling1990HypervariableUT,
  title={Hypervariable ultra-long telomeres in mice},
  author={David Kipling and Howard J. Cooke},
  journal={Nature},
  year={1990},
  volume={347},
  pages={400-402}
}
TELOMERE structure and behaviour is less well understood in vertebrates than it is in ciliates and yeasts (reviewed in ref. 1). Like all other eukaryotic chromosomes, those of vertebrates terminate in an array of a short repeated sequence. In vertebrates this sequence is (TTAGGG)n, as shown by in situ hybridization2,3. In humans, these terminal repeats are heterogeneous in length, averaging about 10 kilobases in blood cells4–6. Here we report the structure and inheritance of the terminal… 

Telomere Variation in Xenopus laevis

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Analysis of the flanking sequences suggested that s-ITSs were inserted during the repair of DNA double-strand breaks that occurred in the course of evolution, and an extensive comparative analysis of the s- ITS loci and their orthologous ‘empty’ loci confirmed this hypothesis.

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Regulation of Telomere Length in Mammalian Cells

The ends of linear mammalian chromosomes consist of a simple repeated sequence (T2AG3)n [reviewed in 1,2]. These terminal repeats play a role in prevention of end to end fusion and prot7ection from

Chromosome ends: different sequences may provide conserved functions

  • E. LouisA. Vershinin
  • Biology
    BioEssays : news and reviews in molecular, cellular and developmental biology
  • 2005
The similarities and diversity that exist among the structural elements, DNA sequences and proteins, that make up terminal domains (telomeres and subtelomeres), and how organisms use these in different ways to fulfil the functions of end‐replication and end‐protection are focused on.

Mouse telocentric sequences reveal a high rate of homogenization and possible role in Robertsonian translocation.

This work has identified large-insert fosmid clones that span the telomere and centromere of several mouse chromosome ends and indicates a possible mechanism for occasional inverted mispairing and recombination between the oppositely oriented TLC and minor satellite repeats to result in Robertsonian translocations.
...

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