Hypervariable region sequence in cryoglobulin-associated hepatitis C virus in sera of patients with chronic hepatitis C: relationship to antibody response against hypervariable region genome.

@article{Aiyama1996HypervariableRS,
  title={Hypervariable region sequence in cryoglobulin-associated hepatitis C virus in sera of patients with chronic hepatitis C: relationship to antibody response against hypervariable region genome.},
  author={Toshiyuki Aiyama and Kentaro Yoshioka and Akihiko Okumura and Motoe Takayanagi and Kaoru Iwata and Tetsuya Ishikawa and Shinichi Kakumu},
  journal={Hepatology},
  year={1996},
  volume={24 6},
  pages={1346-50}
}
Essential mixed cryoglobulinemia is frequently associated with hepatitis C virus (HCV) infection, with the formation of HCV antigen/antibody complexes. The hypervariable region (HVR) of the HCV E2/NS1 region is thought to include epitopes for neutralizing antibodies, but it remains uncertain whether cryoglobulins (CGs) contain such antibody-bound HCV. Thus… CONTINUE READING