Hypervariable region 1 variants act as TCR antagonists for hepatitis C virus-specific CD4+ T cells.


In various human viral infections, the appearance of mutated epitopes displaying TCR antagonistic activity has been correlated with the severity and persistence of infection. In hepatitis C virus (HCV) infection, where the virus persistence has been associated with the rapid and substantial Ag modifications occurring during replication, TCR antagonism has… (More)


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