Hyperurikämie und Gicht

@article{Tausche2006HyperurikmieUG,
  title={Hyperurik{\"a}mie und Gicht},
  author={A. K. Tausche and Sina Kristin Unger and Kathrin Richter and Christian Wunderlich and J. Gr{\"a}ssler and B. Roch and H. E. Schr{\"o}der},
  journal={Der Internist},
  year={2006},
  volume={47},
  pages={509-522}
}
ZusammenfassungDie Hyperurikämie gehört in unserer Wohlstandsgesellschaft zu einer der häufigsten Stoffwechselstörungen. So ist derzeit jeder 4. Mann und jede 10. Frau von einer asymptomatischen oder symptomatischen Hyperurikämie betroffen, wobei letztere als Gicht bezeichnet wird. Zumeist führen Über- und Fehlernährung sowie andere sekundäre Faktoren bei einer genetisch determinierten renalen Ausscheidungsstörung für Harnsäure zum Anstieg der Serumharnsäure. Durch Ablagerung von Harns… 
Neue Aspekte zur Pathogenese der Gicht
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New findings on the pathophysiology of gout are demonstrated, which involve the activation of further cells and an IL-8-mediated neutrophil influx into the joint, and the role of the NOD-like receptor NALP3, which functions as a pattern recognition receptor (PRR).
Gicht und andere Störungen des Purinstoffwechsels
Purine werden mit der Nahrung aufgenommen oder im Organismus aus kleinen Bruchstucken aufgebaut. Als Endprodukt des Purinstoffwechsels entsteht beim Menschen Harnsaure. Die Purinsynthese ist in ⊡
Ernährungstherapie häufiger Erkrankungen des Erwachsenenaltersund des Seniums
Wie auch im Kindesalter muss die Ernahrungstherapie bei Erwachsenen auf die in spezifischen Altersabschnitten vermehrt auftretenden Besonderheiten abgestimmt werden. Wahrend insgesamt bei Erwachsenen
Dual Energy: Gout
TLDR
Gout is a heterogeneous group of disorders characterized by deposition of monosodium urate crystals in the joints and tendons that can be found in the distal extremities, especially adjacent to joints, primarily in the toes but also in the fingers.
[New aspects of the pathogenesis of gout. Danger signals, autoinflammation and beyond].
TLDR
The physiological role of MSU crystals might be that of a danger signal in peripheral tissues, where they stimulate dendritic cell maturation and the role of PRRs such as the NLR is underlined by NALP3 mutations causing hereditary autoinflammatory syndromes and NOD2 polymorphisms as genetic risk factors for Crohn's disease.
Serum uric acid, hyperuricemia and body mass index in children and adolescents with intellectual disabilities.
Conductimetric Biosensor for the Detection of Uric Acid by Immobilization Uricase on Nata de Coco Membrane—Pt Electrode
TLDR
A conductimetric enzyme biosensor for uric acid detection has been developed and demonstrates a linear response to urate over the concentration range 1–6 ppm and has good selectivity properties.

References

SHOWING 1-10 OF 41 REFERENCES
Gout and hyperuricemia.
TLDR
It is recommended that one pay more attention to dietary manipulation in patients with gout in addition to managing hypertension, obesity, and other medical problems.
Excellent uricosuric efficacy of benzbromarone in cyclosporin-A-treated renal transplant patients: a prospective study.
  • R. Zürcher, H. Bock, G. Thiel
  • Medicine, Biology
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
  • 1994
TLDR
Due to its excellent efficacy and lack of significant side-effects, benzbromarone appears to be preferable to allopurinol in CsA-treated renal transplant recipients with a creatinine clearance over 25 ml/min.
When to investigate for purine and pyrimidine disorders. Introduction and review of clinical and laboratory indications
TLDR
These disorders should be suspected in any case of unexplained anaemia, failure to thrive, susceptibility to recurrent infection, or neurological deficits with no current diagnosis, including autism, cerebral palsy, delayed development, deafness, epilepsy, self-mutilation, muscle weakness, the inability to walk or talk, and - unusual in children and adolescents - gout.
Association of the human urate transporter 1 with reduced renal uric acid excretion and hyperuricemia in a German Caucasian population.
OBJECTIVE Human urate transporter 1 (hURAT1) is a member of the organic anion transporter family (SLC22A12) that mainly regulates tubular urate reabsorption. Loss-of-function mutations result in
Pharmacology of drugs for hyperuricemia. Mechanisms, kinetics and interactions.
  • F. Pea
  • Biology, Medicine
    Contributions to nephrology
  • 2005
TLDR
Rasburicase probably undergoes peptide hydrolysis and in in vitro studies was shown neither to inhibit or induce cytochrome P450 isoenzymes nor to interact with several drugs, so that no relevant interaction is expected during cotreatment in patients.
Severe gouty arthritis refractory to anti-inflammatory drugs: treatment with anti-tumour necrosis factor alpha as a new therapeutic option.
TLDR
A 53 year old man with a history of gouty arthritis extending over several years had an acute kidney failure 2 years previously because of nephrolithiasis with urate calculi and had arterial hypertension and hypertriglyceridaemia.
Gout: can management be improved?
TLDR
A low carbohydrate, high protein and unsaturated fat diet was recommended for gouty patients since they all enhance insulin sensitivity and therefore may promote a reduction in serum uric acid levels.
[Uric acid crystals and chemotactic cytokines--pathogenesis of an acute gout attack].
  • P. Peichl
  • Medicine, Biology
    Wiener medizinische Wochenschrift
  • 1997
TLDR
High levels of interleukin-8, a powerful neutrophil attractant with activating properties, were demonstrated in the synovial fluid of patients with acute gout arthritis.
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