Hyperuricemia induces endothelial dysfunction.

  title={Hyperuricemia induces endothelial dysfunction.},
  author={Uday M Khosla and Sergey Zharikov and Jennifer L Finch and Takahiko Nakagawa and Carlos Guilhermo Piscoya Roncal and Wei Mu and Karina Y Krotova and Edward R. Block and Sharma S. Prabhakar and Richard J Johnson},
  journal={Kidney international},
  volume={67 5},
BACKGROUND Hyperuricemia has been linked to cardiovascular and renal diseases, possibly through the generation of reactive oxygen species (ROS) and subsequent endothelial dysfunction. The enzymatic effect of xanthine oxidase is the production of ROS and uric acid. Studies have shown that inhibiting xanthine oxidase with allopurinol can reverse endothelial dysfunction. Furthermore, rat studies have shown that hyperuricemia-induced hypertension and vascular disease is at least partially reversed… CONTINUE READING
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