Hyperuricemia induces a primary renal arteriolopathy in rats by a blood pressure-independent mechanism.

@article{Mazzali2002HyperuricemiaIA,
  title={Hyperuricemia induces a primary renal arteriolopathy in rats by a blood pressure-independent mechanism.},
  author={Marilda Mazzali and John Kanellis and Lin Han and Lili Feng and Yi-Yang Xia and Qiang Chen and Duk-Hee Kang and Katherine L. Gordon and Susumu Kiryu Watanabe and Toshinobu Nakagawa and Huiyao Lan and Richard J Johnson},
  journal={American journal of physiology. Renal physiology},
  year={2002},
  volume={282 6},
  pages={
          F991-7
        }
}
Hyperuricemia is associated with hypertension and vascular disease, but whether this represents a causal relationship or an epiphenomenon remains unknown. We recently reported a model of mild hyperuricemia in rats that results in increased blood pressure and mild renal fibrosis. In this study, we examined the effect of hyperuricemia on the renal vasculature. Rats fed 2% oxonic acid and a low-salt diet for 7 wk developed mild hyperuricemia (1.8 vs. 1.4 mg/dl, P < 0.05), hypertension [147 vs. 127… CONTINUE READING

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