Hypertrophy of the Inferior Olivary Nucleus in Patients with Progressive Supranuclear Palsy

@article{Hanihara1998HypertrophyOT,
  title={Hypertrophy of the Inferior Olivary Nucleus in Patients with Progressive Supranuclear Palsy},
  author={Tokiji Hanihara and Naoji Amano and Tatsuya Takahashi and Yoji Itoh and Saburo Yagishita},
  journal={European Neurology},
  year={1998},
  volume={39},
  pages={97 - 102}
}
Hypertrophic changes in the inferior olivary nuclei have been occasionally described in patients with progressive supranuclear palsy (PSP). To elucidate the incidence of olivary hypertrophy, we investigated morphologically the olives and their associated pathways in 20 autopsied cases: 11 cases of PSP, 3 cases of Machado-Joseph disease and 6 cases of dentatorubropallidoluysian atrophy (DRPLA) as control diseases that usually exhibited lesions of the cerebellofugal pathway. Olivary hypertrophy… 
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    Bailliere's clinical neurology
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TLDR
The clinical and neuropathological features characteristic of progressive supranuclear palsy and corticobasal degeneration are described in detail and suggested symptomatic therapies may improve the quality of life of patients with these disorders.
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