Hypertrophy is induced during the in vitro chondrogenic differentiation of human mesenchymal stem cells by bone morphogenetic protein-2 and bone morphogenetic protein-4 gene transfer

@inproceedings{Steinert2009HypertrophyII,
  title={Hypertrophy is induced during the in vitro chondrogenic differentiation of human mesenchymal stem cells by bone morphogenetic protein-2 and bone morphogenetic protein-4 gene transfer},
  author={Andr{\'e} Steinert and Benedikt Proffen and Manuela Kunz and Christian Hendrich and Steven C. Ghivizzani and Ulrich Noeth and Axel Rethwilm and Jochen Eulert and Christopher H. Evans},
  booktitle={Arthritis research & therapy},
  year={2009}
}
INTRODUCTION The present study compares bone morphogenetic protein (BMP)-4 and BMP-2 gene transfer as agents of chondrogenesis and hypertrophy in human primary mesenchymal stem cells (MSCs) maintained as pellet cultures. METHODS Adenoviral vectors carrying cDNA encoding human BMP-4 (Ad.BMP-4) were constructed by cre-lox combination and compared to previously generated adenoviral vectors for BMP-2 (Ad.BMP-2), green fluorescent protein (Ad.GFP), or firefly luciferase (Ad.Luc). Cultures of human… CONTINUE READING

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