Hypertrophic scar cells fail to undergo a form of apoptosis specific to contractile collagen-the role of tissue transglutaminase.

@article{Linge2005HypertrophicSC,
  title={Hypertrophic scar cells fail to undergo a form of apoptosis specific to contractile collagen-the role of tissue transglutaminase.},
  author={Claire Linge and Janette Richardson and Charlotte Vigor and Elisabeth Clayton and Bushan Hardas and Kerstinj Rolfe},
  journal={The Journal of investigative dermatology},
  year={2005},
  volume={125 1},
  pages={72-82}
}
Failure of apoptosis has been postulated to cause the hypercellularity and thus excess scar-tissue formation of hypertrophic scars (HTS). Here, we have examined the susceptibility of fibroblasts derived from normal or HTS to apoptosis induced during collagen-gel contraction, a wound-healing model. Normal scar (NS) fibroblasts underwent significant apoptosis (>40% total) in contractile collagen, whereas apoptosis was not detected in HTS cells. This inability was specific to apoptosis induced by… CONTINUE READING

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