Hypertrophic repair of canine articular cartilage in osteoarthritis after anterior cruciate ligament transection.

@article{Adams1991HypertrophicRO,
  title={Hypertrophic repair of canine articular cartilage in osteoarthritis after anterior cruciate ligament transection.},
  author={Mark E. Adams and Kenneth D. Brandt},
  journal={The Journal of rheumatology},
  year={1991},
  volume={18 3},
  pages={428-35}
}
Transection of the anterior cruciate ligament in the dog is used frequently to produce a model of osteoarthritis (OA). Although it results in metabolic, biochemical, biomechanical and morphological changes in the articular cartilage of the unstable knee which resemble those in human OA, it rarely results in full thickness cartilage loss. The lack of progression of the cartilage lesions in this model has generally been attributed to stabilization of the joint by osteophytes and capsular fibrosis… CONTINUE READING

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