Hypertrophic differentiation during chondrogenic differentiation of progenitor cells is stimulated by BMP-2 but suppressed by BMP-7.

@article{Caron2013HypertrophicDD,
  title={Hypertrophic differentiation during chondrogenic differentiation of progenitor cells is stimulated by BMP-2 but suppressed by BMP-7.},
  author={Marjolein M J Caron and Pieter J. Emans and Andy Cremers and Don A. M. Surtel and Marielle M. E. Coolsen and Lodewijk W. van Rhijn and Tim Welting},
  journal={Osteoarthritis and cartilage},
  year={2013},
  volume={21 4},
  pages={604-13}
}
OBJECTIVE Bone morphogenic protein (BMP)-2 and BMP-7 are clinically approved and their recombinant proteins are used for bone tissue regenerative purposes and widely evaluated for cartilage regeneration. Previous comparison of the in vitro chondrogenic characteristics of BMP-2 vs BMP-7 did not address hypertrophic differentiation and characterizing their chondrogenic properties with a focus in on chondrocyte hypertrophy was topic of investigation in this study. DESIGN Equimolar concentrations… CONTINUE READING
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