Hypertrophic differentiation and calcification during intervertebral disc degeneration.

  title={Hypertrophic differentiation and calcification during intervertebral disc degeneration.},
  author={Joost P H J Rutges and Robin Duit and Jean Alain Kummer and Fetullah Cumhur Oner and Mattie H. P. van Rijen and Abraham J. Verbout and Ren{\'e} M. Castelein and W. J. A. Dhert and Laura B. Creemers},
  journal={Osteoarthritis and cartilage},
  volume={18 11},
BACKGROUND In degenerative intervertebral discs (IVDs) collagen type X expression and calcifications have been demonstrated, resembling advanced osteoarthritis (OA), which is associated with hypertrophic differentiation, characterized by the production of collagen type X, Runt-related transcription factor 2 (Runx2), osteoprotegerin (OPG), alkaline phosphatase (ALP) and calcifications. OBJECTIVE The aim of this study was to determine if hypertrophic differentiation occurs during IVD… CONTINUE READING