Hypertrophic cardiomyopathy-related beta-myosin mutations cause highly variable calcium sensitivity with functional imbalances among individual muscle cells.

@article{Kirschner2005HypertrophicCB,
  title={Hypertrophic cardiomyopathy-related beta-myosin mutations cause highly variable calcium sensitivity with functional imbalances among individual muscle cells.},
  author={Sebastian E Kirschner and Edgar Becker and Massimo Antognozzi and H. P. Kubis and Antonio Francino and Francisco Navarro-L{\'o}pez and Nana Bit-Avragim and Andreas Perrot and Mirsaid M. Mirrakhimov and Karl-Josef Osterziel and William J. McKenna and Bernhard Dipl Phys Brenner and Theresia Kraft},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2005},
  volume={288 3},
  pages={
          H1242-51
        }
}
Disease-causing mutations in cardiac myosin heavy chain (beta-MHC) are identified in about one-third of families with hypertrophic cardiomyopathy (HCM). The effect of myosin mutations on calcium sensitivity of the myofilaments, however, is largely unknown. Because normal and mutant cardiac MHC are also expressed in slow-twitch skeletal muscle, which is more easily accessible and less subject to the adaptive responses seen in myocardium, we compared the calcium sensitivity (pCa(50)) and the… CONTINUE READING

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References

Publications referenced by this paper.
SHOWING 1-10 OF 41 REFERENCES

Mutation of the myosin converter domain alters cross-bridge elasticity.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 2002
VIEW 9 EXCERPTS
HIGHLY INFLUENTIAL

Hypertrophic cardiomyopathy

VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

The effect of myosin light chain 2 dephosphorylation on Ca2 -sensitivity of force is enhanced in failing human hearts

J Van der Velden, Z Papp, +5 authors GJ. Stienen
  • Cardiovasc Res
  • 2003
VIEW 5 EXCERPTS
HIGHLY INFLUENTIAL

VARIABLE CA2 SENSITIVITY IN HCM MYOSIN MUTANTS AJP-Heart

J Van der Velden, Z Papp, +7 authors GJ. Stienen
  • Circ Physiol
  • 2005
VIEW 2 EXCERPTS

VARIABLE CA2 SENSITIVITY IN HCM MYOSIN MUTANTS AJP-Heart

J Van der Velden, Z Papp, +7 authors GJ. Stienen
  • Circ Physiol
  • 2005
VIEW 2 EXCERPTS