Hypertriglyceridemia is exacerbated by slow lipolysis of triacylglycerol-rich lipoproteins in fed but not fasted streptozotocin diabetic rats.

@article{Mamo1992HypertriglyceridemiaIE,
  title={Hypertriglyceridemia is exacerbated by slow lipolysis of triacylglycerol-rich lipoproteins in fed but not fasted streptozotocin diabetic rats.},
  author={John C. L. Mamo and Tsutomu Hirano and Amanda Sainsbury and A. Kenneth Fitzgerald and Trevor G. Redgrave},
  journal={Biochimica et biophysica acta},
  year={1992},
  volume={1128 2-3},
  pages={132-8}
}
Hydrolysis by endothelial lipases of triacylglycerol-rich lipoproteins of diabetic origin were compared to lipoproteins of non-diabetic origin. The plasma lipoprotein fraction of density < 1.006 g/ml, including chylomicrons and VLDL, were incubated in vitro with post-heparin plasma (PHP) lipases. The lipoproteins of diabetic origin were hydrolysed at a significantly slower rate than lipoproteins from normal rats by the lipoprotein lipase component of PHP. However, if rats were fasted for 16 h… CONTINUE READING

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