Hypertonicity activates nonselective cation channels in mouse cortical collecting duct cells.

@article{Volk1995HypertonicityAN,
  title={Hypertonicity activates nonselective cation channels in mouse cortical collecting duct cells.},
  author={Tilmann Volk and Eberhard Fr{\"o}mter and Christoph Korbmacher},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1995},
  volume={92 18},
  pages={8478-82}
}
We investigated the effect of cell shrinkage on whole-cell currents of M-1 mouse cortical collecting duct cells. Addition of 100 mM sucrose to an isotonic NaCl bath solution induced cell shrinkage and increased whole-cell currents within 5-10 min by approximately 12-fold. The effect was reversible upon return to isotonic solution and could also be elicited by adding 100 mM urea or 50 mM NaCl. Replacement of bath Na+ by K+, Cs+, Li+, or Rb+ did not significantly affect the stimulated inward… CONTINUE READING
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