Hypertonic saline resuscitation decreases susceptibility to sepsis after hemorrhagic shock.

Abstract

BACKGROUND We hypothesized that improvements in cellular immune function after hypertonic saline (HTS) resuscitation will alter the outcome of sepsis after hemorrhage. METHODS To test this hypothesis, a two-hit model was used. Hemorrhage was induced in BALB/c mice by catheterizing the femoral artery and bleeding until a mean arterial pressure = 35 mm Hg… (More)

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