Hypertonic saline nasal provocation stimulates nociceptive nerves, substance P release, and glandular mucous exocytosis in normal humans.

@article{Baraniuk1999HypertonicSN,
  title={Hypertonic saline nasal provocation stimulates nociceptive nerves, substance P release, and glandular mucous exocytosis in normal humans.},
  author={James N. Baraniuk and Muttaher H. Ali and Atsushi Yuta and S. Y. Fang and K Naranch},
  journal={American journal of respiratory and critical care medicine},
  year={1999},
  volume={160 2},
  pages={
          655-62
        }
}
  • James N. Baraniuk, Muttaher H. Ali, +2 authors K Naranch
  • Published 1999
  • Medicine
  • American journal of respiratory and critical care medicine
  • Hypertonic saline (HTS) induces bronchoconstriction. Potential mechanisms were evaluated in a human nasal provocation model. Aliquots of normal saline (1 x NS, 100 microliters) and higher concentrations (3 x NS, 6 x NS, 12 x NS, 24 x NS) were sprayed into one nostril at 5-min intervals. Lavage fluids were collected from the ipsilateral and contralateral sides to determine the concentrations of specific mucus constituents. Nasal cavity air-space volume was assessed by acoustic rhinometry (AcRh… CONTINUE READING

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