Hypertonic saline nasal provocation stimulates nociceptive nerves, substance P release, and glandular mucous exocytosis in normal humans.

@article{Baraniuk1999HypertonicSN,
  title={Hypertonic saline nasal provocation stimulates nociceptive nerves, substance P release, and glandular mucous exocytosis in normal humans.},
  author={James N. Baraniuk and Mushtaq Ali and Atsushi Yuta and Sheng Yun Fang and Kristina Naranch},
  journal={American journal of respiratory and critical care medicine},
  year={1999},
  volume={160 2},
  pages={655-62}
}
Hypertonic saline (HTS) induces bronchoconstriction. Potential mechanisms were evaluated in a human nasal provocation model. Aliquots of normal saline (1 x NS, 100 microliters) and higher concentrations (3 x NS, 6 x NS, 12 x NS, 24 x NS) were sprayed into one nostril at 5-min intervals. Lavage fluids were collected from the ipsilateral and contralateral sides to determine the concentrations of specific mucus constituents. Nasal cavity air-space volume was assessed by acoustic rhinometry (AcRh… CONTINUE READING
30 Citations
34 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 30 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 34 references

The nasal response to hyperosmolar saline is inhibited by capsaicin treatment (abstract)

  • G. Lai, G. Philip, A. Togias
  • J. Allergy Clin. Immunol
  • 1996

Effects of intranasal administration of endothelin-1 to allergic and nonallergic individuals

  • M. M. Ricchio, C. J. Reynolds, D. W. Hay, D. Proud
  • Am. J. Respir. Crit. Care Med
  • 1995

Similar Papers

Loading similar papers…