Hypertonic saline is a negative inotropic agent in normovolumic dogs.

@article{Constable1994HypertonicSI,
  title={Hypertonic saline is a negative inotropic agent in normovolumic dogs.},
  author={Peter D Constable and W Muir and Philip F. Binkley},
  journal={The American journal of physiology},
  year={1994},
  volume={267 2 Pt 2},
  pages={H667-77}
}
The inotropic effects of hypertonic saline (HS) and hyperosmotic dextrose (HD; 2,400 mosmol/l, 4 ml/kg) were determined in normovolumic, chloralose-anesthetized, intact (n = 14) and autonomically blocked (n = 8) dogs. Solutions were infused intravenously over 3 min. HS and HD rapidly increased preload in both intact and autonomically blocked dogs, as assessed by significant (P < 0.05) increases in plasma volume, end-diastolic volume, and end-diastolic pressure. In intact dogs, HS produced a… CONTINUE READING