Hypertonic saline improves intestinal mucosa barrier function and lung injury after trauma-hemorrhagic shock.

@article{Shi2002HypertonicSI,
  title={Hypertonic saline improves intestinal mucosa barrier function and lung injury after trauma-hemorrhagic shock.},
  author={Han Ping Shi and Edwin A. Deitch and Zhong Da Xu and Q M Lu and Carl J. Hauser},
  journal={Shock},
  year={2002},
  volume={17 6},
  pages={496-501}
}
Our objective was to test the hypotheses that small volume hypertonic saline (HTS) resuscitation protects against trauma-hemorrhagic shock (T/HS)-induced intestinal and lung injury better than standard volume resuscitation with Ringer's lactate (RL), and that the degree of lung injury correlates with the degree of gut injury after therapy. Male Sprague-Dawley rats were subjected to laparotomy (trauma) and 90 min of T/HS or sham shock (T/SS), and were then resuscitated with RL or 7.5% NaCl… CONTINUE READING
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