Hypertonic saline for cystic fibrosis.

@article{Aziz2006HypertonicSF,
  title={Hypertonic saline for cystic fibrosis.},
  author={Imran Aziz and Jack A. Kastelik},
  journal={The New England journal of medicine},
  year={2006},
  volume={354 17},
  pages={
          1848-51; author reply 1848-51
        },
  url={https://api.semanticscholar.org/CorpusID:26244542}
}
This study does not suggest that the negative findings of the Honer study resulted from an inadequate dose of risperidone, and found no evidence of bias in terms of pharmaceutical-industry sponsorship on the efficacy data from the randomized, controlled trials comparing secondgeneration with first-generation antipsychotic agents.
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New and investigational treatments in cystic fibrosis

Treatments for CF and its manifestations are discussed in this article including inhaled antibiotics, hydrator therapies, anti-inflammatory agents and protein modifiers, new and experimental treatments that are in development are also discussed.

Comparison of effects of 3 and 7% hypertonic saline nebulization on lung function in children with cystic fibrosis: a double-blind randomized, controlled trial.

3% hypertonic saline nebulization was better than 7% saline inhalation in children with cystic fibrosis, and there is a need for studies with larger sample size and longer duration to confirm the results.

Absence of CFTR is associated with pleiotropic effects on mucins in mouse gallbladder epithelial cells.

Mucus of cystic fibrosis patients exhibits altered biochemical composition and biophysical behavior, but the causal relationships between altered cystic fibrosis transmembrane conductance regulator…

Using Serious Games to Motivate Children with Cystic Fibrosis to Engage with Mucus Clearance Physiotherapy

Game software which is controlled through breathing into a PEP mask or mouthpiece using an air pressure sensor to interface with the PC could provide a powerful means of encouraging children, teenagers and adults to engage more frequently and effectively with vital mucus clearance physiotherapy.

21 References

A controlled trial of long-term inhaled hypertonic saline in patients with cystic fibrosis.

Hypertonic saline preceded by a bronchodilator is an inexpensive, safe, and effective additional therapy for patients with cystic fibrosis.

The CF salt controversy: in vivo observations and therapeutic approaches.

Effect of increasing doses of hypertonic saline on mucociliary clearance in patients with cystic fibrosis.

There was a significant increase in the amount of activity cleared from the right lung with all concentrations of hypertonic saline (HS) compared with control, and within the range of concentrations examined in this study, the effect of hyperTONic saline appears to be dose dependent.

Comparison of hypertonic saline and alternate-day or daily recombinant human deoxyribonuclease in children with cystic fibrosis: a randomised trial

Risk of death in cystic fibrosis patients with severely compromised lung function.

In the patient population of patients with cystic fibrosis, a cutoff value of FEV1 of < 30% predicted is not a reliable predictor of high risk of death within 2 years, and the yearly rate of decline of percent predictedFEV1 is a better parameter to identify those patients at high risk for death.

Rheology of cystic fibrosis sputum after in vitro treatment with hypertonic saline alone and in combination with recombinant human deoxyribonuclease I.

In vitro results suggest that combined treatment with rhDNase and HS should be evaluated further as a potential mucotropic approach to augment the clearance of purulent sputum in CF lung disease.

Effect of rhDNase on airflow obstruction and mucociliary clearance in cystic fibrosis.

The results indicate that aerosolized rh DNase improves FEV1 and FVC independent of CPT, and it is unable to demonstrate that rhDNase reduces airflow obstruction or improves mucociliary clearance.

Short‐term efficacy of ultrasonically nebulized hypertonic saline in cystic fibrosis

In patients with CF, ultrasonically nebulized hypertonic saline improves lung function in a way similar to that reported for human recombinant DNase when inhaled over a 2 week period.

Effect of a short course of rhDNase on cough and mucociliary clearance in patients with cystic fibrosis

The aim of the study was to measure the effect of a short course of recombinant human deoxyribonuclease I (rhDNase) on ciliary and cough clearance in a group of cystic fibrosis patients, using a…

Mucus clearance and lung function in cystic fibrosis with hypertonic saline.

In patients with cystic fibrosis, inhalation of hypertonic saline produced a sustained acceleration of mucus clearance and improved lung function, and in vitro data suggested that sustained hydration of airway surfaces was responsible for the sustained improvement in mucus clearing.