Hypertonic saline enhances cellular immune function.

  title={Hypertonic saline enhances cellular immune function.},
  author={Wolfgang G. Junger and Forrest C. Liu and William H. Loomis and David Butler Hoyt},
  journal={Circulatory shock},
  volume={42 4},
Hypertonic saline (HTS) resuscitation improves outcome after trauma. We studied the effect of HTS on immune function. In vitro T-cell proliferation of human and rabbit peripheral blood mononuclear cells (PBMC) was doubled at 25 mM increased extracellular Na+ concentrations. Further increased hypertonicity (more than 40 mM with human cells, and 80 mM with rabbit cells) caused progressive suppression of proliferation. Human and rabbit monocyte functions (tumor necrosis factor production) were… CONTINUE READING


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