Hypertonic saline-dextran suppresses burn-related cytokine secretion by cardiomyocytes.

  title={Hypertonic saline-dextran suppresses burn-related cytokine secretion by cardiomyocytes.},
  author={J. Wright Horton and David L. Maass and Jean White and B Sanders},
  journal={American journal of physiology. Heart and circulatory physiology},
  volume={280 4},
Whereas hypertonic saline-dextran (HSD, 7.5% NaCl in 6% D70) improves cardiac contractile function after burn trauma, the mechanisms of HSD-related cardioprotection remain unclear. We recently showed that cardiomyocytes secrete tumor necrosis factor-alpha (TNF-alpha), a response that was enhanced by burn trauma. This study addressed the question: does HSD modulate cardiac contraction/relaxation by altering cardiomyocyte TNF-alpha secretion? Wistar-Furth rats (325 g) were given a burn injury… CONTINUE READING


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