Hypertonic saline alters plasma clotting times and platelet aggregation.

@article{Reed1991HypertonicSA,
  title={Hypertonic saline alters plasma clotting times and platelet aggregation.},
  author={Robert Lawrence Reed and Thomas Charles Duffin Johnston and Yu-Ray Chen and R. P. Fischer},
  journal={The Journal of trauma},
  year={1991},
  volume={31 1},
  pages={8-14}
}
Hypertonic (7.5%) saline (HS) is advocated for resuscitation of injured and burned patients. Recent animal studies indicate that HS increases bleeding during uncontrolled hemorrhage, although the mechanisms for this are unclear. To investigate potential anticoagulant effects of HS (without dextran), normal human plasma was serially diluted with either HS or normal (0.9%) saline (NS). Prothrombin times (PT), activated partial thromboplastin times (APTT), and platelet aggregation studies were… CONTINUE READING
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