Hypertonic saline, not mannitol, should be considered gold-standard medical therapy for intracranial hypertension

@inproceedings{Marko2012HypertonicSN,
  title={Hypertonic saline, not mannitol, should be considered gold-standard medical therapy for intracranial hypertension},
  author={Nicholas Marko},
  booktitle={Critical care},
  year={2012}
}
Hyperosmolar therapy is the principal medical management strategy for elevated intracranial pressure. Mannitol has been the primary hyperosmolar agent for nearly a century and remains the de facto gold standard for medical management of intracranial hypertension. Over the past 25 years, however, hypertonic saline (HTS) has become a progressively more common alternative to mannitol, and several recent studies have suggested its relative superiority. These findings have prompted calls for large… CONTINUE READING
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