Hypertonic immunomodulation is reversible and accompanied by changes in CD11b expression.

@article{Rizoli1999HypertonicII,
  title={Hypertonic immunomodulation is reversible and accompanied by changes in CD11b expression.},
  author={Sandro Rizoli and Andr{\'a}s Kapus and Jean C Parodo and Jie Fan and Ori D. Rotstein},
  journal={The Journal of surgical research},
  year={1999},
  volume={83 2},
  pages={130-5}
}
BACKGROUND In a two-hit model of hemorrhagic shock and lipopolysaccharide (LPS), we previously showed that hypertonic saline (HTS) resuscitation reduced lung sequestration of neutrophils and the accompanying injury. This effect was partially attributed to suppressed expression of the surface adhesion molecule CD11b. This study investigates the duration of this protective effect after a single HTS dose and the usefulness of repeated infusions. MATERIAL AND METHODS The previous two-hit rodent… CONTINUE READING