Hyperthermic preconditioning severely accelerates neuronal damage in the gerbil ischemic hippocampal dentate gyrus via decreasing SODs expressions.

@article{Kim2015HyperthermicPS,
  title={Hyperthermic preconditioning severely accelerates neuronal damage in the gerbil ischemic hippocampal dentate gyrus via decreasing SODs expressions.},
  author={Dong Won Kim and J H Cho and Geum-Sil Cho and In Hye Kim and Joon Ha Park and Ji Hyeon Ahn and Bai hui Chen and Bich-Na Shin and Hyun-Jin Tae and Seongkweon Hong and Jun Hwi Cho and Y. -B. Kim and Moo-Ho Won and Jae-Chul Lee},
  journal={Journal of the neurological sciences},
  year={2015},
  volume={358 1-2},
  pages={266-75}
}
It is well known that neurons in the dentate gyrus (DG) of the hippocampus are resistant to short period of ischemia. Hyperthermia is a proven risk factor for cerebral ischemia and can produce more extensive brain damage related with mortality rates. The aim of this study was to examine the effect of hyperthermic conditioning (H) on neuronal death, gliosis and expressions of SODs as anti-oxidative enzymes in the gerbil DG following 5 min-transient cerebral ischemia. The animals were randomly… CONTINUE READING