Hyperthermia protects mice against the lethal effects of endotoxin.

  title={Hyperthermia protects mice against the lethal effects of endotoxin.},
  author={Richard S Hotchkiss and I Nunnally and Susan Lindquist and J Taulien and George Perdrizet and I S Karl},
  journal={The American journal of physiology},
  volume={265 6 Pt 2},
Recently, investigators have reported that heat shock proteins (HSPs) can protect isolated cells from cytotoxicity induced by two important mediators of sepsis: interleukin-1 and tumor necrosis factor. The present study was undertaken to examine the hypothesis that transient whole body hyperthermia could decrease mortality from subsequent challenge with gram-negative endotoxin. We demonstrate that heat pretreatments improved long-term survival fivefold in a mouse endotoxin model and this was… CONTINUE READING
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