Hyperthermia mediated liposomal drug delivery.

@article{Ponce2006HyperthermiaML,
  title={Hyperthermia mediated liposomal drug delivery.},
  author={A. M. Ponce and Zeljko Vujaskovi{\'c} and Fan Yuan and D. Needham and Mark W. Dewhirst},
  journal={International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group},
  year={2006},
  volume={22 3},
  pages={205-13}
}
Drug delivery systems have been developed for cancer therapy in an attempt to increase the tumour drug concentration while limiting systemic exposure. Liposomes have achieved passive targeting of solid tumours through enhanced vascular permeability, which is greatly augmented by hyperthermia. However, anti-tumour efficacy has often been limited by slow release of bioavailable drug within the tumour. Local hyperthermia has become the most widely used stimulus for triggered release of liposomal… CONTINUE READING

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Hyperthermia mediated liposomal drug delivery .
A temperature - sensitive liposome containing doxorubicin has been shown to release 100% of contents through stabilized membrane pores within 10 - 20 s at 41 degrees C. This formulation has exhibited dramatic improvements in pre - clinical drug delivery and tumour regression and is now in clinical trials .
Hyperthermia mediated liposomal drug delivery .
A temperature - sensitive liposome containing doxorubicin has been shown to release 100% of contents through stabilized membrane pores within 10 - 20 s at 41 degrees C. This formulation has exhibited dramatic improvements in pre - clinical drug delivery and tumour regression and is now in clinical trials .
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