Hyperthermia induces IL-1 alpha but does not decrease release of IL-1 alpha or TNF-alpha after endotoxin.

@article{Blake1994HyperthermiaII,
  title={Hyperthermia induces IL-1 alpha but does not decrease release of IL-1 alpha or TNF-alpha after endotoxin.},
  author={Donnevan Blake and Palmer Q. Bessey and I S Karl and I Nunnally and R Hotchkiss},
  journal={Lymphokine and cytokine research},
  year={1994},
  volume={13 5},
  pages={271-5}
}
Heat treatments administered prior to the onset of sepsis or endotoxemia markedly increase survival. A potential mechanism for the beneficial effect of heat could be effects on IL-1 alpha and TNF-alpha, important mediators of sepsis and endotoxemia. Administration of IL-1 or TNF prior to development of sepsis and endotoxemia increases survival; thus, prophylactic heat treatments may protect by releasing IL-1 or TNF. Paradoxically, an alternative mechanism of protection of prophylactic heat… CONTINUE READING