Hyperthermia-induced targeting of thermosensitive gene carriers to tumors.

@article{Schwerdt2008HyperthermiainducedTO,
  title={Hyperthermia-induced targeting of thermosensitive gene carriers to tumors.},
  author={A. Schwerdt and A. Zintchenko and Massimo Concia and N. Roesen and K. Fisher and L. Lindner and R. Issels and E. Wagner and M. Ogris},
  journal={Human Gene Therapy},
  year={2008},
  volume={19},
  pages={1283-1292}
}
Locoregional hyperthermia (HT) can be used for site-directed activation of macromolecular drug delivery systems. We have developed a gene delivery system based on thermosensitive block copolymers (TSCs) with a phase transition temperature of 42 degrees C [Zintchenko, A., Ogris, M., and Wagner, E. (2006). Bioconjug. Chem. 17, 766-772], in which the statistical copolymer of vinylpyrrolidinone and N-isopropylacryamide is grafted on polyethylenimine (PEI). Here we applied polyplexes consisting of… Expand
26 Citations
Nucleic acid therapeutics: concepts for targeted delivery to solid tumors.
  • M. Ogris
  • Biology, Medicine
  • Therapeutic delivery
  • 2010
Degradable Polyethylenimine-Based Gene Carriers for Cancer Therapy
Nanoparticle preconditioning for enhanced thermal therapies in cancer.
Thermoresponsive gene carriers based on polyethylenimine-graft-poly[oligo(ethylene glycol) methacrylate].
  • R. Zhang, Yang Wang, +4 authors Z. Li
  • Chemistry, Medicine
  • Macromolecular bioscience
  • 2011
Stimuli-sensitive nanopreparations for combination cancer therapy.
Low generation PAMAM dendrimer and CpG free plasmids allow targeted and extended transgene expression in tumors after systemic delivery.
Stimulus-responsive nanopreparations for tumor targeting.
  • Lin Zhu, V. Torchilin
  • Chemistry, Medicine
  • Integrative biology : quantitative biosciences from nano to macro
  • 2013
...
1
2
3
...

References

SHOWING 1-10 OF 43 REFERENCES
Targeted drug delivery by thermally responsive polymers.
Novel Temperature-Sensitive Liposomes with Prolonged Circulation Time
Targeting vaccinia to solid tumors with local hyperthermia.
In vivo tumor transfection mediated by polyplexes based on biodegradable poly(DMAEA)-phosphazene.
Local hyperthermia improves uptake of a chimeric monoclonal antibody in a subcutaneous xenograft model.
Specific targets in tumor tissue for the delivery of therapeutic genes.
Hyperthermia in combined treatment of cancer.
A local hyperthermia treatment which enhances antibody uptake in a glioma xenograft model does not affect tumour interstitial fluid pressure.
...
1
2
3
4
5
...