Hyperthermia increases interleukin-6 in mouse skeletal muscle.

@article{Welc2012HyperthermiaII,
  title={Hyperthermia increases interleukin-6 in mouse skeletal muscle.},
  author={Steven S. Welc and Neil A. Phillips and Jose A. Oca-Cossio and Shannon Margaret Wallet and Daniel L. Chen and Thomas L Clanton},
  journal={American journal of physiology. Cell physiology},
  year={2012},
  volume={303 4},
  pages={
          C455-66
        }
}
Skeletal muscles produce and contribute to circulating levels of IL-6 during exercise. However, when core temperature is reduced, the response is attenuated. Therefore, we hypothesized that hyperthermia may be an important and independent stimulus for muscle IL-6. In cultured C2C12 myotubes, hyperthermia (42°C) increased IL-6 gene expression 14-fold after 1 h and 35-fold after 5 h of 37°C recovery; whereas exposure to 41°C resulted in a 2.6-fold elevation at 1 h. IL-6 protein was secreted and… CONTINUE READING

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