Hyperthermia increases cerebral metabolic rate and blood flow in neonatal pigs.

  title={Hyperthermia increases cerebral metabolic rate and blood flow in neonatal pigs.},
  author={David William Busija and Charles W. Leffler and Massroor Pourcyrous},
  journal={The American journal of physiology},
  volume={255 2 Pt 2},
We examined effects of hyperthermia on cerebral metabolic rate for oxygen (CMRO2) and cerebral blood flow (CBF) in anesthetized, newborn pigs (2-5 days old). CBF and CMRO2 were measured during normothermia (38 degrees C) and during hyperthermia induced by body heating (42 degrees C). During normothermia, total CBF was 32 +/- 3 ml.min-1.100 g-1 (n = 9), and CMRO2 was 1.34 +/- 0.08 ml O2.100 g-1.min-1 (n = 7). During hyperthermia, total CBF increased by 97 +/- 23% and CMRO2 by 65 +/- 24%. We also… CONTINUE READING

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