Hyperthermia as a teratogen: parameters determining hyperthermia-induced head defects in the rat.

@article{Germain1985HyperthermiaAA,
  title={Hyperthermia as a teratogen: parameters determining hyperthermia-induced head defects in the rat.},
  author={Michel A. Germain and William S Webster and Marsh J Edwards},
  journal={Teratology},
  year={1985},
  volume={31 2},
  pages={265-72}
}
This study determined the relationship between the duration and extent of temperature elevation, during a critical period of rat embryonic development, and the induction of congenital malformations. Pregnant Sprague-Dawley rats, at 9 days 12 hours gestation (gastrulation stage), were partially immersed in a water bath until their core temperature, monitored by a rectal thermistor probe, was elevated to a nominated temperature. Seven temperatures were tested from 40.5 degrees C to 43.5 degrees C… CONTINUE READING

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Hyperthermia: malformations to chaperones.

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