Hyperthermia and antinociceptive activity of thyrotropin-releasing hormone and morphine following central administration in rats.

@article{Zhukov1988HyperthermiaAA,
  title={Hyperthermia and antinociceptive activity of thyrotropin-releasing hormone and morphine following central administration in rats.},
  author={Vyacheslav Zhukov and Krassimira S. Yakimova and I Y Shamyakina},
  journal={Acta physiologica et pharmacologica Bulgarica},
  year={1988},
  volume={14 2},
  pages={18-23}
}
This is an assessment of thyrotropin-releasing hormone (TRH) and morphine effects on nociceptive activity and temperature reaction in male Wistar rats following introduction of the substances into the periaqueductal gray matter or preoptic anterior hypothalamic nuclei via before hand cannulation. Morphine (10 micrograms) had marked antinociceptive activity, as shown by the tail flick-test, hot plate-test and mechanical pressure according to Randall-Selitto. TRH (5 micrograms) showed… CONTINUE READING

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