Hyperthermia Combined with Chemotherapy – Biological Rationale, Clinical Application, and Treatment Results

@article{Issels1999HyperthermiaCW,
  title={Hyperthermia Combined with Chemotherapy – Biological Rationale, Clinical Application, and Treatment Results},
  author={Rolf D. Issels},
  journal={Oncology Research and Treatment},
  year={1999},
  volume={22},
  pages={374 - 381}
}
  • R. Issels
  • Published 1 October 1999
  • Medicine
  • Oncology Research and Treatment
There is substantial evidence from preclinical data that the antitumor cytotoxicity of selected chemotherapeutic agents either alone or combined with radiation can be enhanced by appropriate heat exposure (40–44 °C) of cells or tumor tissues. Based upon these results the integration of hyperthermia as an additional treatment modality, given simultaneously with systemic chemotherapy or in combination with radiochemotherapy, is currently tested at the clinic. Regional hyperthermia combined with… 

Figures and Tables from this paper

The cellular and molecular basis of hyperthermia.

Integrating Loco-Regional Hyperthermia Into the Current Oncology Practice: SWOT and TOWS Analyses

TLDR
Hyperthermia along with immune checkpoint inhibitors and DNA damage repair inhibitors could further augment the therapeutic efficacy resulting in synthetic lethality, and could gainfully accomplish a safe, versatile, and cost-effective enhancement of the existing therapeutic armamentarium to improve outcomes in clinical oncology.

A moderate thermal dose is sufficient for effective free and TSL based thermochemotherapy.

Current and Potential Role of Thermoradiotherapy for Solid Tumours

TLDR
An ongoing investigation of hyperthermia in multimodal treatment strategies for locally advanced solid tumours is warranted and trials will help to improve temperature monitoring and temperature distribution and define particular groups of patients who will profit from the addition ofhyperthermia.

The regimen of gemcitabine and cisplatin combined with radio frequency hyperthermia for advanced non-small cell lung cancer: A phase II study

TLDR
Radio-frequency regionalhyperthermia in combination with chemotherapy (GP) is a safe, well tolerated, and effective therapeutic modality for patients with advanced NSCLC and the addition of hyperthermia improved quality of life.

Thermoradiotheraphy of cancer: An effective approach

TLDR
An overview on the application of HT combined with conventional cancer treatment modalities, mainly radiotherapy, and results of randomized trials form Western research groups are provided to provide an overview.

Synergistic chemotherapy by combined moderate hyperthermia and photochemical internalization.

TLDR
The combination of PCI and MHT resulted in significant increases in BLM efficacy at 44°C for both cell line derived spheroids compared to controls at 37°C over the range of radiant exposures examined.
...

References

SHOWING 1-10 OF 57 REFERENCES

The current and potential role of hyperthermia in radiotherapy.

  • J. Overgaard
  • Medicine
    International journal of radiation oncology, biology, physics
  • 1989

Preoperative hyperthermia combined with radiochemotherapy in locally advanced rectal cancer: a phase II clinical trial.

TLDR
Preoperative HRCT is feasible and effective and may contribute to locoregional tumor control of advanced rectal cancer, which is to be proven in an ongoing phase III trial.

Hyperthermo-chemo-radiotherapy for patients with early carcinoma of the esophagus.

TLDR
An accurate diagnosis of the esophageal lesion and appropriate selection of potentially treatable cases are considered essential for the optimal use of HCR therapy in patients with submucosal carcinoma.

Intraoperative radiotherapy and hyperthermia for unresectable pancreatic cancer.

TLDR
IORT plus EBRT can be recommended for unresectable but localized pancreatic cancer associated with low tumor marker levels and high-dose IORT (30 Gy) + E BRT (40-60 Gy) was more effective than EBRt alone in patients with a CA 19-9 level < 1000 U/ml.

Sensitivity of hyperthermia trial outcomes to temperature and time: implications for thermal goals of treatment.

Multi-institutional clinical studies on hyperthermia combined with radiotherapy or chemotherapy in advanced cancer of deep-seated organs.

  • M. KakehiK. Ueda S. Nakatsugawa
  • Medicine
    International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group
  • 1990
TLDR
It was indicated that hyperthermia was one of the most effective treatment techniques for advanced or inoperable cases and in improving the quality of life of patients under terminal care.

Molecular and Cellular Mechanisms of Hyperthermia

TLDR
The focus of this chapter will be on the action of heat alone, which means that the clonogenicity of stem cells is destroyed by agents such as ionizing radiation, cytotoxic chemicals, or heat.

Hyperthermia combined with chemotherapy and irradiation for patients with carcinoma of the oesophagus--a prospective randomized trial.

  • K. SugimachiK. Kitamura H. Kuwano
  • Medicine
    International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group
  • 1992
TLDR
It is suggested that preoperative HCR therapy may be a more beneficial therapy than preoperative CR therapy in patients with squamous cell carcinoma of the oesophagus who undergo a subtotal oesphagectomy.
...