Hyperthermia Combined with Chemotherapy – Biological Rationale, Clinical Application, and Treatment Results

  title={Hyperthermia Combined with Chemotherapy – Biological Rationale, Clinical Application, and Treatment Results},
  author={Rolf D. Issels},
  journal={Oncology Research and Treatment},
  pages={374 - 381}
  • R. Issels
  • Published 1 October 1999
  • Medicine
  • Oncology Research and Treatment
There is substantial evidence from preclinical data that the antitumor cytotoxicity of selected chemotherapeutic agents either alone or combined with radiation can be enhanced by appropriate heat exposure (40–44 °C) of cells or tumor tissues. Based upon these results the integration of hyperthermia as an additional treatment modality, given simultaneously with systemic chemotherapy or in combination with radiochemotherapy, is currently tested at the clinic. Regional hyperthermia combined with… 

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