Hypertensive rats exhibit heightened expression of corticotropin-releasing factor in activated central neurons in response to restraint stress.

@article{Krukoff1999HypertensiveRE,
  title={Hypertensive rats exhibit heightened expression of corticotropin-releasing factor in activated central neurons in response to restraint stress.},
  author={Teresa L. Krukoff and David Mactavish and Jack H. Jhamandas},
  journal={Brain research. Molecular brain research},
  year={1999},
  volume={65 1},
  pages={70-9}
}
To test the hypothesis that chronically elevated sympathetic drive is associated with hyperreactiveness of autonomic centers in the brain to stress, adult spontaneously hypertensive rats (SHRs) and two strains of normotensive rats (Wistar Kyoto [WKY] and Sprague Dawley [SD] rats) were acutely exposed to restraint stress; controls from each strain were not stressed. Brain sections were prepared for Fos immunohistochemistry to identify activated neurons in the paraventricular nucleus of the… CONTINUE READING