Hypertensive diabetic rats in pharmacological studies.

  title={Hypertensive diabetic rats in pharmacological studies.},
  author={Peter Adriaan van Zwieten and Kwee Lan Kam and A. J. van der Pijl and Maarten Hendriks and O. H. M. Beenen and Martin Pfaffendorf},
  journal={Pharmacological research},
  volume={33 2},
Since hypertensive disease and diabetes frequently occur simultaneously there exists a requirement for animal models where both pathological entities are combined. The streptozotocin (STZ)-spontaneously hypertensive rat (STZ-SHR) and the obese Zucker rat are examples of animal models where hypertension and diabetes occur simultaneously. STZ-SHRs develop a hyperglycaemic syndrome, associated with other biochemical and morphological changes that to some extent approach insulin-dependent diabetes… CONTINUE READING


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