Hypertensive Urgency Induced by an Interaction of Mirtazapine and Clonidine

  title={Hypertensive Urgency Induced by an Interaction of Mirtazapine and Clonidine},
  author={Reem A Abo-Zena and Mary Beth Bobek and Raghad Dweik},
  journal={Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy},
Mirtazapine is a new antidepressant with a tetracyclic chemical structure that is not related to selective serotonin reuptake inhibitors, tricyclic antidepressants, or monoamine oxidase inhibitors. The antidepressant effect results from stimulation of the noradrenergic system through antagonism at central a2‐inhibitory receptors. Clonidine exerts its antihypertensive effect by stimulating these receptors to cause a reduction in endogenous release of norepinephrine. Therefore, the two agents… Expand
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Hypertensive Crisis Induced by Interaction of Clonidine with Imipramine
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This case report describes a hypertensive emergency that occurred in an elderly woman, probably as a result of an interaction between clonidine and imipramine, used not as an antidepressant but as an agent in the management of urinary incontinence. Expand
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  • Medicine
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The unique pharmacology of mirtazapine means that it has a very different side effect profile from the tricyclic antidcpressants, producing less α1 adrenergic and musearinic blockade and causing much less nausea and sexual dysfunction. Expand
Interaction between Clonidine and Desipramine in Man
Introduction of a tricyclic antidepressant may lead to loss of blood pressure control in a hypertensive patient treated with clonidine in a double-blind placebo controlled study. Expand
Hypertension during coprescription of mirtazapine and low-dose amitriptyline.
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