Hypertension is critically dependent on the carotid body input in the spontaneously hypertensive rat.

@article{Abdala2012HypertensionIC,
  title={Hypertension is critically dependent on the carotid body input in the spontaneously hypertensive rat.},
  author={Ana P Abdala and Fiona Mcbryde and Nephtali Marina and Emma B. Hendy and Zoar J. Engelman and Marat Fudim and Paul Andrew Sobotka and Alexander V. Gourine and Julian Paton},
  journal={The Journal of physiology},
  year={2012},
  volume={590 17},
  pages={4269-77}
}
The peripheral chemoreflex is known to be enhanced in individuals with hypertension. In pre-hypertensive (PH) and adult spontaneously hypertensive rats (SHRs) carotid body type I (glomus) cells exhibit hypersensitivity to chemosensory stimuli and elevated sympathoexcitatory responses to peripheral chemoreceptor stimulation. Herein, we eliminated carotid body inputs in both PH-SHRs and SHRs to test the hypothesis that heightened peripheral chemoreceptor activity contributes to both the… CONTINUE READING

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