Hypertension impairs leptomeningeal collateral growth after common carotid artery occlusion: restoration by antihypertensive treatment.

@article{OmuraMatsuoka2011HypertensionIL,
  title={Hypertension impairs leptomeningeal collateral growth after common carotid artery occlusion: restoration by antihypertensive treatment.},
  author={Emi Omura-Matsuoka and Yoshiki Yagita and Tsutomu Sasaki and Yasukazu Terasaki and Naoki Oyama and Yukio Sugiyama and Kenichi Todo and Saburo Sakoda and Kazuo Kitagawa},
  journal={Journal of neuroscience research},
  year={2011},
  volume={89 1},
  pages={108-16}
}
Chronic mild hypoperfusion has been shown to enlarge pial collateral vessels in normal mouse brains. The purpose of this study was to clarify the effect of hypertension on pial collateral vessel development after chronic hypoperfusion using spontaneously hypertensive rats (SHR). In normotensive rats, unilateral common carotid artery (CCA) occlusion enlarged leptomeningeal collateral vessels. CCA occlusion also preserved residual cerebral blood flow (CBF) and attenuated infarct size after middle… CONTINUE READING